Andrew Garfield and Emma Stone will return as Peter Parker - aka Spider-Man - and Gwen Stacy, while Jamie Foxx has signed on to portray Electro, Shailene Woodley will play Mary Jane Watson and Dane DeHaan Harry Osborne.
And now Sideways star Giamatti and Felicity Jones look set to join the cast.
The Rhino is a dream role for the actor, who has previously admitted to being a big fan of the invincible character.
In a 2011 interview, he said, ""I thought Rhino was the greatest thing when I was a little kid. It was a guy who was basically in this rhinoceros outfit and I always thought, 'Why don't they have The Rhino in one of their movies?'""